Stress wakes up sleeping herpes viruses – but how?
Hiding their DNA genome inside the nuclei of the infected cells, the herpes viruses establish a lifelong infection in humans. Poorly defined stress conditions are known to wake up these parasites from...
View ArticlePancreatic cancer: Major breakthrough in our understanding of the mechanisms...
Pancreatic cancer carries a very bleak prognosis for patients. However, a recent breakthrough by two research teams, including one at the Hôpital Maisonneuve-Rosemont (CIUSSS-EST, Montreal) and...
View ArticleFamily support buffers the physiological effects of racial discrimination
African American adolescents who experience high levels of racial discrimination show cellular wear and tear, according to new research published in Psychological Science, a journal of the Association...
View ArticleThe causes of premature ageing of neurons in Parkinson's patients
Researchers at the Luxembourg Centre for Systems Biomedicine (LCSB) of the University of Luxembourg and partners in Constance, Munich and Bochum are studying the causes of premature ageing of neurons...
View ArticleCellular aging process unexpectedly enhances insulin secretion
New research shows that a cellular program that causes aging can also bring unexpected benefits in the function of pancreatic beta cells and the production of insulin in mice and humans. The findings...
View ArticleScientists identify sensor that modulates key metabolic pathway
Only recently have scientists begun to tease apart the molecular links between specific nutrients and mTORC1, a cellular signaling pathway that controls growth and metabolism. Now Whitehead Institute...
View ArticleResearchers uncover how kappa opioid receptors drive anxiety
University of North Carolina researchers uncovered a cellular mechanism by which kappa opioid receptors (KOR) drive anxiety. These proteins inhibit the release of the neurotransmitter glutamate in a...
View ArticleScientists discover genetic basis of reactive oxygen species increase
An international team of scientists has determined under which conditions a body produces more superoxide—a dangerous form of oxygen able to destroy DNA. The article was published in Free Radical...
View ArticleHIV can develop resistance to CRISPR/Cas9
The CRISPR/Cas9 gene-editing platform may need a little bit more tweaking before it can be used as an effective antiviral, reports a study published April 7 in Cell Reports. Researchers who used...
View ArticleHow diet influences our genes
What we eat can directly affect the genetic programs that regulate cellular function. A new EU project, coordinated by an LMU researcher, will explore how the products of metabolism intervene in gene...
View ArticleQuieting cells' low-oxygen alarm stops flare-ups in rare bone disorder
The cellular response to the lack of oxygen fans the flames of flare-ups in a rare bone disorder. In fibrodysplasia ossificans progressiva (FOP), a mutation triggers bone growth in muscles, which...
View ArticleCommon antacid linked to accelerated vascular aging
Chronic use of some drugs for heartburn and gastroesophageal reflux (GERD) speeds up the aging of blood vessels, according to a published paper in Circulation Research (early online), an American Heart...
View ArticleFreight train: Myo1c provides cellular transport for protein crucial to...
The motor protein Myo1c binds to Neph1, a protein crucial for ensuring effective filtration by the kidney, and serves as one mode of its cellular transport, according to findings by investigators at...
View ArticleRhythm of 'detox' and feeding genes in fruitflies and mice coordinated by...
A 24-hour rhythm of cellular detoxification in flies and mammals is coordinated by a neuropeptide that also drives feeding in both organisms, found a team led by Amita Sehgal, PhD, a professor of...
View ArticleEnhanced arginine metabolism may counteract inflammation pathways in asthma
High arginine levels are often observed in asthmatic individuals and may support increased production of nitric oxide, which is known to worsen airway inflammation. Medications that reduce arginine...
View ArticleNew findings challenge current view on origins of Parkinson's disease
The neurodegeneration that occurs in Parkinson's disease is a result of stress on the endoplasmic reticulum in the cell rather than failure of the mitochondria as previously thought, according to a...
View ArticleViral protein silences immune alarm signals
Viruses must avoid a host's immune system to establish successful infections—and scientists have discovered another tool that viruses use to frustrate host defenses. Researchers from The Children's...
View ArticleNatural metabolite can suppress inflammation
An international group of scientists from the U.S., Canada, Germany and Russia has revealed a naturally occurring organic compound that can suppress the pro-inflammatory activity of macrophages. The...
View ArticleNew hope in search for migraine cure
Migraine attacks are suffered by millions of people worldwide but despite significant progress in treatment in recent years an effective cure continues to elude scientists.
View ArticleNew molecules protect brain after mild traumatic brain injury
Whether at school, in car accidents, on the sports field or the battlefield, mild traumatic brain injury (mTBI) is a common part of our lives. It is especially frequent among children, athletes, and...
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