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Rhythm of 'detox' and feeding genes in fruitflies and mice coordinated by neuropeptide

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A 24-hour rhythm of cellular detoxification in flies and mammals is coordinated by a neuropeptide that also drives feeding in both organisms, found a team led by Amita Sehgal, PhD, a professor of Neuroscience and director of the Chronobiology Program, in the Perelman School of Medicine at the University of Pennsylvania. Their findings were published this month in eLife. Sehgal is also a Howard Hughes Medical Institute (HHMI) investigator.

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