Researchers find lower caloric intake provides a benefit to middle-aged, but...
Calorie restriction has long been studied as a way to extend lifespan in animals. It has been associated with the ability to reduce the risks of cardiovascular and other diseases and to improve overall...
View ArticleStudy identifies molecular link between DNA damage and premature aging
Like a beloved pair of jeans, human DNA accumulates damage over time, and older people's bodies can't repair it as well. Many scientists believe a build up of damage can cause cells to enter an...
View ArticleResearchers discover key driver of human aging
A study tying the aging process to the deterioration of tightly packaged bundles of cellular DNA could lead to methods of preventing and treating age-related diseases such as cancer, diabetes and...
View ArticleOxidative stress is an aggravating factor in Lafora rare disease
Neurodegenerative Lafora disease usually becomes apparent through seizures during adolescence and puberty and occurs as a consequence of defects in glycogen metabolism and in the cellular mechanisms...
View Article'Master controller' behind DNA structure reorganization during senescence...
Senescence, a phenomenon in which cells cease to divide and grow, can be caused by everything from natural DNA damage to treatment with chemotherapy. However, several mechanisms allow for cells to...
View ArticleController in the cell
Quality control is important – this is not only applicable to industrial production but also true for all life processes. However, whereas an enterprise can start a large-scale recall in case of any...
View ArticleScientists identify new drug target to treat ALS
Scientists from the Gladstone Institutes and the University of Michigan have identified a cellular mechanism that can be targeted to treat ALS. The researchers revealed that increasing levels of a...
View ArticleTelomere shortening linked to early aging, death among poor in Detroit
The stress of living in extreme poverty causes early onset of age-related diseases and takes years off the lives of many of the urban poor—evidence at the cellular level now shows, according to a...
View ArticlePotential treatment target identified for rare form of diabetes, other disorders
Cell death can trigger numerous diseases, including a rare and severe form of diabetes known as Wolfram syndrome. The cascade of cell death occurs when molecules spill from one part of a cell into...
View ArticleSchwann cells 'dine in' to clear myelin from injured nerves
Researchers reveal how cells in the peripheral nervous system (PNS) degrade myelin after nerve injury, a process that fails to occur in the central nervous system (CNS). The study appears in The...
View ArticleNew paradigm for treating 'inflammaging' and cancer
Intermittent dosing with rapamycin selectively breaks the cascade of inflammatory events that follow cellular senescence, a phenomena in which cells cease to divide in response to DNA damaging agents,...
View ArticleAge-related self-destruction of cells makes kidney prone to injury
As advances in medicine allow individuals to live longer, people are facing unique age-related health challenges. As they age, organs such as the kidneys become more susceptible to injury, and their...
View ArticleConventional wisdom overlooks links between chemical mixtures and cancer
Conventional thinking about cancer prevention may overlook growing evidence that the combined effects of chemicals that are not carcinogenic on their own may be a significant cause of cancer, according...
View ArticleDNA damage seen in patients undergoing CT scanning, study finds
Using new laboratory technology, scientists have shown that cellular damage is detectable in patients after CT scanning, according to a new study led by researchers at the Stanford University School of...
View ArticleCell phone notifications may be driving you to distraction
Whether you are alerted to an incoming phone call or text by a trendy ringtone, an alarm bell or a quiet vibration, just receiving a notification on your cell phone can cause enough of a distraction to...
View ArticleAn imbalance of cellular bioenergetics in pancreatic beta-cells links to type...
Impaired activation of mitochondrial energy metabolism in the presence of glucose has been demonstrated in pancreatic beta-cells from patients with type 2 diabetes. The cause of this dysfunction has...
View ArticleCellular factors that shape the 3-D landscape of the genome identified
Researchers, using novel large-scale imaging technology, have mapped the spatial location of individual genes in the nucleus of human cells and identified 50 cellular factors required for the proper...
View ArticlePartnership aims to replace animal experiments with advanced liver-on-chip...
Safety evaluation is a critical part of drug and cosmetic development. In recent years there is a growing understanding that animal experiments fail to predict the human response, necessitating the...
View ArticleDevice will deliver skin cell regeneration to treat burns, hard-to-heal...
Avita Medical Ltd, a regenerative medicine company specialising in the treatment of wounds and skin defects, today announced that it has forged a partnership with the University of Huddersfield to...
View ArticleStudy uncovers anticonvulsant effects of valproic acid
University of California, Irvine researchers with the School of Medicine have identified the mechanism by which valproic acid controls epileptic seizures, and by doing so, also revealed an underlying...
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